▲

PROFILE

Home  Colleges  College of Basic Sciences and Humanities  Department of Biochemistry  Profile

Department of Biochemistry


Dr. S.K. Dubey


DESIGNATION:Assistant Professor
QUALIFICATION:Ph.D.
SPECIALISATION:Cancer chemoprevention, Cancer stem cells, Curcumin bioconjugates
EMAIL:shivdub[at]gmail[dot]com
sk[dot]dubey[at]gbpuat-cbsh[dot]ac[dot]in
CONTACT NO.:+91-7905091550 (M)

Teaching Experience and Courses Taught

Teaching Experience: 8 years

Courses Taught are as follows

  • Elementary Plant Biochemistry BBC-261
  • Fundamentals of Biochemsitry BBC-361
  • Chemistry of Biomiolecules BBC-500
  • General Biochemistry BBC-501
  • Basic techniques in Biochemistry BBC-505
  • Biochemical techniques BBC-510
  • Food and Nutritional Biochemistry BBC-620
  • Intermediary metabolism-I BBC-641
  • Intermediary metabolism-II BBC-642
  • Plant Biochemistry BBC-645
  • Animal Biochemistry BBC-651
  • Carbon and Nitrogen metabolism BBC-655
  • Advanced techniques in Biochemistry BBC-710
  • Biomembranes BBC-751
  • Current Topics in Biochemistry BBC-765
    • Research Interests

  • Natural products, Cancer chemoprevention, Bioprospecting
    • Research Projects

  • PI in Uttarakhanad Council for Biotechnology funded project on Design, synthesis, characterization, in silico and in vitro evaluation of novel curcumin analogs as adjunct drugs targeting breast cancer stem cells (CSCs) (2023-2026) (Budget : 11.35 Lakhs)
  • Co-PI in DST funded project on “Synthesis, characterization and testing of immune-potential of nano-particles adjuvanted oral vaccine of Salmonella typhimurium in Poultry. (2020-2023) (Budget: 44.039 Lakhs)
    • Publications

    e-Content   Developed 22 e-content text modules for the course” Fundamentals of Biochemistry”.


    Research Papers

    1. Mahawer S, Kumar R, Prakash O, Rawat DS, Dubey SK, Olivera M. (2023). A review of phytochemical and pharmacological properties of Alpina malaccenis (Burm. F.) Roscoe. (Zingiberaceae) Current topics in Medicinal Chemistry (Accepted) (IF- 3.57)
    2. Pujari R, Dubey SK*. (2023) Relevance of glyco-biomakers and glycan profiles in cancer stem cells. Glycobiology (Accepted) https://doi.org/10.1093/glycob/cwad019 (IF- 6)

    3. Bahuguna A, Dubey SK*, Garia V, Kumar R, Prakash O, Rawat DS. (2023) Composition, antioxidant, and anti-inflammatory activities of different polarity extracts of Anaphalis busua from the Himalayan terrain of Uttarakhand. European journal of Chemistry, 14(1), 114-120. https://dx.doi.org/10.5155/eurjchem.14.1.114-120.2395 (IF- 0.6)

    4. Sethi S, Prakash O, Kumar R, Dubey SK, Arya M, Pant A. (2022) Phytochemical Analysis, Antioxidant and Antifungal Activity of Essential oil and Extracts of Alpiniamalaccensis (Burm.f.) Roscoe flowers. Brazilian Journal of Pharmaceutical Sciences 58, e201209 DOI: 10.1590/s2175-97902022e201209 (IF- 1.21)

    5. Gairola K, Gururani S, Kumar R, Prakash O, Agarwal S, Dubey SK*. (2022) Composition, Antioxidant and Anti-inflammatory activities of Hexane and Methanol extracts of Acmella uliginosa form Terai region of Uttarakhand. Brazilian Journal of Pharmaceutical Sciences 58, e20353 DOI: 10.1590/s2175-97902022e20353 (IF- 1.21)

    6. Kabdal T, Himani, Kumar R, Prakash O, Nagarkoti K, Rawat DS, Srivastava RM, Kumar S, Dubey SK (2022) Seasonal variation in the essential oil composition and biological activities of Thymus linearis Benth. collected from Kumaun region of Uttarakhand, India. Biochemical Systematics and Ecology103 (2022) 104449. https://doi.org/10.1016/j.bse.2022.104449 (IF- 1.462)

    7.  Gururani S, Gairola K, Kumar R, Prakash O, Agarwal S, Dubey SK*. (2022) Altitudinal variations in phytochemical composition and biological activities of Curcuma longa accession from Uttarakhand, Himalayan region. Journal of food processing and preservation 46(3) e16384.DOI: 10.1111/jfpp.16384 (IF- 2.60)

    8. Gairola K, Gururani S, Bahuguna A, Garia V, Pujari R, Dubey SK*. (2021) Natural products targeting cancer stem cells: Implications for cancer chemoprevention and therapeutics. Journal of Food Biochemistry. 24(7)e13772 https://doi.org/10.1111/jfbc.13772 (IF- 3.65)

    9. Gairola K, Gururani S, Kumar R, Prakash O, Agarwal S, Dubey SK*. (2021) Composition, Antioxidant and Anti-inflammatory activities of essential oil of Acmellauliginosa from Terai region of Uttarakhand. Trends in Phytochemical research.5(1), 44-52. https://doi.org/10.30495/tpr.2021.680495

    10. Mishra H, Kesharwani RK*, Singh DV, Tripathi S, Dubey SK*, Misra K.(2019) Computational simulation of inhibitory effects of curcumin, retinoic acid, and their conjugates for GSK-3 beta. Network Modeling Analysis in Health Informatics and Bioinformatics. 8: 3. https://doi.org/10.1007/s13721-018-0177-x (IF-1.20)

    11. Srivastava RM, Singh S, Dubey SK, Misra K, Khar A. (2011).Immunomodulatory and therapeutic activities of curcumin. International Immunopharmacology, 119(3), 331-341.DOI: 10.1016/j.intimp.2010.08.014 (IF 5.7)

    12. Kakarala M, Dubey SK, Dobry C, Xijian P, Murillo G, Parikh S, Amarasinghe C, Mehta R, Brenner DE. (2011). VitaminD compounds induce BRCA1 expression and inhibits breast stem cells. Cancer Research, 71(8 supplement) – 1842. https://doi.org/10.1158/1538-7445.AM2011-1842 (IF-13.31)

    13. Krishna S#, Ray A#, Dubey SK#, Larrouy-Maumus G, Chalut C, Castanier R, Noguera A, Gilleron M, Puzo G, Vercellone A, Nampoothiri KM, Nigou J. (2011)Lipoglycans contribute to innate immune detection of mycobacteria. PLoS One, 6(12):e28476.(#equal contribution) DOI: 10.1371/journal.pone.0028476 (IF-3.75)

    14. Mythri RB, Harish G, Dubey SK, Misra K,Bharath MMS. (2011) Glutamoyldiester of the dietary polyphenol curcumin offers improved protection against peroxynitrite mediated nitrosative stress and damage of brain mitochondria in vitro: Implications for Parkinson's disease. Mol Cell Biochem, 347(1-2):135-43.DOI: 10.1007/s11010-010-0621-4 (IF-3.84)

    15. KakaralaM, Dubey SK, TarnowskiM, Cheng C, Liyanage S, Tazi K, Sen A, Djuric Z, Brenner DE. (2010) Ultralow flow liquid chromatography assay with UV detection for piperine quantitation in human plasma. J Agr Food Chem, 58 (11), 6594-6599. DOI: 10.1021/jf100657r (IF-5.89)

    16. Harish G, MythriRB, Venkateshappa C, Dubey SK, Misra K, Singh N, Vali S, Bharath MMS.(2010). Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson disease. Bioorg. Med. Chem, 18, 2631-2638. DOI: 10.1016/j.bmc.2010.02.029 (IF-3.46)

    17. Dubey SK, Sharma AK, Narayan U, Misra K, Pati U.(2008) Design, synthesis, and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenatedpiperic acid and study of their antimicrobial and antiproliferative properties. Eur. J. Med. Chem., 43, 1837-1846. DOI: 10.1016/j.ejmech.2007.11.027 (IF-7.08)

    18. Dubey SK, Dwivedi V,Misra K. (2007) Novel method for synthesis of monoesters of symmetric diphenolic compounds like curcumin (1, 7-Bis (4-hydroxy-3-methoxy phenyl) 1, 6-hepta diene-3, 5-dione) via solid phase synthesis. Synthetic communication, 37, 4265-4271. https://doi.org/10.1080/00397910701575863 (IF-1.93)

    19. Dubey SK, Pandey A, Mishra R, Kapoor N, Misra K.(2007)Site specific drug delivery by non-viral mode. Indian journal of biotechnology, 6, 159-174. (IF-0.324)

    20. Dubey SK, Pandey A, Bajaj AK, Misra K.(2007)Some commercial azo dyes as Inhibitors of mushroom tyrosinase DOPA oxidase activity. Journal of Pharmacology and toxicology, 2(8), 718-724. DOI: 10.3923/jpt.2007.718.724

    21. Dubey SK, Misra K,Tiwari A, Bajaj AK. (2006).Chemically induced pigmentary changes of human skin: interaction of some azo dyes with human DNA. Journal of pharmacology and toxicology, 1(3), 234-247. DOI: 10.3923/jpt.2006.234.247

    22. Dubey SK, Sharma A,Kumar A, Pati U, Tiwari A, Misra K. (2006) Design and synthesis of a modified RNA-curcumin-demethylenatedpiperoyl conjugate as a telomerase targeted antisense prodrug, its activity against human cancer cell lines Hela& KB. Medicinal Chemistry Research, 15(1-6), 164-165.https://doi.org/10.1007/s00044-006-1503-x. (IF-2.351)

    23. Bajaj AK, Dubey SK, Misra K. (2004) A simple spectroscopic technique proposed for scanning the depigmenting potential for azo dyes. Contact Dermatitis, 51(2), 97-98.DOI: 10.1111/j.0105-1873.2004.0396j.x (IF-6.419)
    Books/Book Chapters

    Book Edited/Adapted

  • Editor of the book entitled “Natural Products and nano-formulations in Cancer Chemoprevention’ to be published by CRC Press (2023)
  • Contributed additional content and questions with answers for the development of 4 book chapters in an Indian adaption of the book “Textbook of Biochemistry with Clinical Correlations”, 7th Edition by Thomas M. Devlin (Editor) Published by Wiley India (2022) (ISBN 9789354641558)

    • Book Chapters

    1. Gururani S, Gairola K, Dubey SK*. (2022), Antioxidant and immunomodulationIn: Kesharwani, R.K., Keservani, R.K., Sharma, A.K. (eds) Immunomodulators and Human Health. Springer, Singapore. pp 101-121, https://doi.org/10.1007/978-981-16-6379-6_4ISBN- 978-981-16-6378-9
    2. Gairola K, Gururani S, DubeySK*. (2022), Polyphenols and its effect on immune system, In: Kesharwani, R.K., Keservani, R.K., Sharma, A.K. (eds) Nutraceuticals and Functional Foods in Immunomodulators. Springer, Singapore.pp. 121-140DOI:https://doi.org/10.1007/978-981-19-2507-8_5ISBN- 978-981-19-2506-1
    3. Gairola K, Dubey SK*, BahugunaA, Shruti. (2023),Nutrigenomics in cancer chemoprevention. In Dubey SK(Ed.) Natural products and nano-formulations in cancer chemoprevention, CRC Press pp. 165-181
    4. Bahuguna A, Dubey SK*, Gairola K, Pujari R.(2023), Overview of natural products and Nano formulations in cancer chemoprevention. in Dubey SK (Ed.) Natural products and nano-formulations in cancer chemoprevention, CRC Press pp. 1-19
    5. Naudiyal N, Rana GS, Adhikari A, Dubey SK.(2023), Fat SolubleVitamins in Cancer Chemoprevention.inDubey SK (Ed.) Natural products and nano-formulations in cancer chemoprevention, CRC Press pp. 39-55
    UG/PG/PHD student information

  • Supervised 6 PG Thesis
  • Currently guiding 03 Ph.D. students
    • Patents

    Patents Filed

  • IPMC/Patent-IPRs/F.No.-29/479 on 12/03/2018. (Application No: 201811008983) A lime processed turmeric powder with enhanced recovery of nanoforms of curcuminoids inducing mesenchymal stem cells derived osteoblast differentiation and mineralization.” Inventors: Anil Kumar, Manoj Singh, NavedAkhtar, WaseemAkramMalla, Pallavi Shah, Shiv Kumar Dubey and S. P. Singh
    • Additional responsibilities

  • Co-staff counselor for Basic Sciences and Humanities Society (2021-23)
  • Co-faculty Secretary for the Board of Faculty of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar (2022-23)
  • Joint Coordinator, B.Tech (Biotech) program, C.B.S.H., G.B. Pant University of Agriculture and Technology, Pantnagar. (2022-23)
  • Staff counselor PG Society, G.B. Pant University of Agriculture and Technology, Pantnagar (2022-23)
    • Professional Achievements and Awards

    Honors/Awards

  • 2002   Qualified NET-LS (National Eligibility Test for lectureship) and JRF (Junior Research Fellowship) conducted by UGC-CSIR, India
  • 1999   Bronze Medal in B.Sc. Biology Group, Ewing Christian College, University of Allahabad.India.
  • 2022   Best researcher award in the International Research Awards on Science, Technology and Management - INSO, Organized by VDGOOD Professional Association, India.

    • Post Doctoral Experience:

  • May 2009 - Dec 2011:   Postdoc Fellow, University of Michigan, Ann Arbor, MI, USA
  • Apr 2007 - Mar 2009:   Postdoc Fellow, Institute of Pharmacology and Structural Biology,CNRS, Toulouse, France

    • Membership of the professional bodies

  • Life member of “Society of Biological Chemists”, India.
  • Life member of “National Academy of Biological Sciences”, India.
    • Links

    Google Scholar Link:   Click Here

    Research Gate account Link:   Click Here

     ORCID Id:   Click Here