Dr. Mumtesh Kumar Saxena

Research Areas / Areas of Interest

• Genetic Engineering with special reference to the development of sub-unit vaccine
• Molecular marker for analysis of genetic variations
• Application of nano-adjuvant systems for vaccine delivery

Research Projects

1. Assessment of Salmonella status in Gangetic water from Gangotri to Varanasi — Department of Science and Technology, Government of India (2005-2008)
2. Characterization of potent protective antigens of Pasteurella multocida and development of recombinant DNA vaccine — Department of Biotechnology, Government of India (2005-2008)
3. Serological and molecular characterization of etiological agents of Inclusion Body Hepatitis and hydro-pericardium syndrome in fowl with special reference to development of suitable vaccine — Department of Biotechnology, Government of India (2005-2008)
4. Molecular Typing and Virulence gene analysis of Salmonella in North India — Department of Biotechnology, Government of India (2007-2010)
5. Expression of Omp28 with special reference to development of r-DNA vaccine of Salmonella (as Project Mentor) — Department of Science and Technology, Government of India (2009-12)
6. Creation of double gene mutant (stn and inv) of Salmonella Typhimurium and testing of immune-potential of mutant — Department of Biotechnology, Government of India (2012-15)
7. Molecular epidemiology of fowl adenoviruses and establishment of their causal association with different clinical conditions in domestic fowl — Indian Council of Agricultural Research, Government of India (2015-2017)
8. Recombinant penton base and fiber proteins of Inclusion Body Hepatitis-Hydropericardium Syndrome virus of poultry: Production and testing of immune-potential — Department of Biotechnology, Government of India (2016-19)
9. Synthesis, Characterization and testing of immune-potential of nanoparticles adjuvanted oral vaccine of Salmonella Typhimurium in poultry (as Project Mentor) — Department of Science and Technology, Government of India (2020-23)
10. Design, synthesis, characterization, in silico and in vitro evaluation of novel curcumin analogs as adjunct drugs testing breast cancer stem cells (as Co-PI) — Uttarakhand Council of Biotechnology (2023-26)

Selected Publications

1. Saxena, A., Singh, Y., Saxena M.K., Kumar, S., Mrigesh, M., Kamboj, A., Verma, M.K., Kandpal, M. and Singh, S.P. 2026. Assessment of the Immune-potential of Calcium Phosphate-Outer Membrane Protein-Nanoparticles (CaP-Omp-Nps) Adjuvanted Nano-Vaccine against Salmonella Typhimurium in poultry birds. Pharmaceutics, 18, 681. https://doi.org/10.3390/pharmaceutics18060681
2. Singh, Y., Kumar, A., Saxena, A., Bhatt, P., Singh, S. P., Kumar, A., Mrigesh, M. and Saxena, M. K. 2022. Assessment of free radicals and reactive oxygen species milieu in nanoparticles adjuvanted outer membrane proteins vaccine against Salmonella Typhi. Archives of Microbiology, 204(8), 479.
3. Singh, Y., Saxena, A., Singh, S. P., Verma, M. K., Kumar, A., Kumar, A., Mrigesh, M. and Saxena, M. K. 2022. Calcium phosphate adjuvanted nanoparticles of outer membrane proteins of Salmonella Typhi as a candidate for vaccine development against Typhoid fever. Journal of Medical Microbiology, 71(4), 001529.
4. Tamuly, S. and Saxena, M. K. 2012. Preparation of Calcium phosphate nanoparticles and evaluation of their effects on muscle cells of rat. Current Science, 610-612.
5. Saxena, M. K., Singh, V. P., Kumar, A. A., Chaudhuri, P., Singh, V. P., Shivachandra, S. B. and Sharma, B. 2006. REP-PCR analysis of Pasteurella multocida isolates from wild and domestic animals in India. Veterinary Research Communications, 30(8), 851-861.

Other Information

• Recipient of Fellowships awarded by the Council of Scientific and Industrial Research (CSIR), Indian Council of Agricultural Research (ICAR), Department of Science and Technology (DST) and Department of Biotechnology (DBT), Government of India.
• The research team has been felicitated more than 15 times by various International, National and State scientific societies in seminars, conferences and symposiums.