Home/Colleges/Basic Sciences & Humanities/Biochemistry/Dr. S.K. Dubey
Dr. S.K. Dubey
Department of Biochemistry

Dr. S.K. Dubey

Assistant Professor
  • DesignationAssistant Professor
  • QualificationPh.D.
  • SpecialisationCancer chemoprevention, Cancer stem cells, Curcumin bioconjugates
  • Emailshivdub@gmail.com
    skdubey.bbc@gbpuat.ac.in
  • Contact No.+91-7905091550 (M)

Teaching Experience & Courses Taught

Teaching Experience: 10 years

Courses Taught are as follows:

  • Elementary Plant Biochemistry BBC-261
  • Fundamentals of Biochemistry BBC-361
  • Chemistry of Biomolecules BBC-500
  • General Biochemistry BBC-501
  • Basic techniques in Biochemistry BBC-505
  • Biochemical techniques BBC-510
  • Food and Nutritional Biochemistry BBC-620
  • Intermediary metabolism-I BBC-641
  • Intermediary metabolism-II BBC-642
  • Plant Biochemistry BBC-645
  • Animal Biochemistry BBC-651
  • Carbon and Nitrogen metabolism BBC-655
  • Advanced techniques in Biochemistry BBC-710
  • Biomembranes BBC-751
  • Current Topics in Biochemistry BBC-765

Research Interests

  • Natural products
  • Cancer chemoprevention
  • Bioprospecting

Research Projects

  • PI in Uttarakhand Council for Biotechnology funded project on Design, synthesis, characterization, in silico and in vitro evaluation of novel curcumin analogs as adjunct drugs targeting breast cancer stem cells (CSCs) (2023-2026) (Budget: 11.35 Lakhs)
  • Co-PI in DST funded project on Synthesis, characterization and testing of immune-potential of nano-particles adjuvanted oral vaccine of Salmonella typhimurium in Poultry (2020-2023) (Budget: 44.039 Lakhs)
  • Co-PI in DST funded project on Collection, screening and cataloguing Fagopyrum spp. Cultivars from Himalayan regions and development of package and practices followed by value addition for livelihood enhancement of SC communities 2025-26 (18 months) (Budget: 46.236 Lakhs)

Publications

e-Content: Developed 22 e-content text modules for the course “Fundamentals of Biochemistry”.

Research Papers

  1. Bhandari S, Gairola K, Bahuguna A, Pujari R, Rawat DS, Prakash O, Dubey SK*. (2026) Phytochemical Profiling and Antioxidant Potential of Acmella ciliata Essential Oil: Experimental Analysis and in-silico Evaluation. In silico Research in Biomedicine, 100525, DOI: 10.1016/j.insi.2026.100525
  2. Kumar P, Bahuguna A, Gairola K, Pujari R, Rawat DS, Prakash O, Kumar R, Dubey SK*. (2026) Phytochemistry and bioefficacy of Ageratum houstonianum leaf and flower essential oils: antioxidant, anti-inflammatory, and molecular docking studies. Plant Biosystem 160, 161. https://doi.org/10.1007/s44473-026-00172-y (IF- 1.8)
  3. Kabdal T, Prakash O, Singh S, Arya S, Kumar R, Dubey SK, Chaturvedi P, Kumar S (2026) Green Solutions With Plagiochasma appendiculatum: Nutraceutical and Pesticidal Potentials. Chemistry & biodiversity 23 (3), e02977. DOI: 10.1002/cbdv.202502977 (IF- 2.5)
  4. Gairola K, Singh G, Bahuguna A, Pujari R, Keshwarwani, Dubey SK* (2026) Computational simulation guided prediction of the inhibitory effect of Curcumin, Diallyl sulfide, and its conjugates on ALDH1A1 to target Breast Cancer stem cells (BCSCs). Journal of Biomolecular Structure and Dynamics. 44(2), 1024-1037. https://doi.org/10.1080/07391102.2025.2506720 (IF- 2.7)
  5. Bahuguna, Dubey SK. (2025) Computational exploration of curcumin-para coumaric acid bioconjugates as potential inhibitors of beta catenin in breast cancer stem cells. Pantnagar journal of research 23(3): 85-92
  6. Singh S, Prakash O, Arya S, Kabdal T, Kumar R, Mahawer SK, Dubey SK, Rawat DS, Kumar S (2025) Pesticidal potency with dynamic chemical profile: A comprehensive seasonal study of Alpinia nigra (Gaertu.) Burtt Essential oils with possible mechanistic approach. Chemistry and Biodiversity (0): e01784 https://doi.org/10.1002/cbdv.202501784 (IF- 2.5)
  7. Singh S, Prakash O, Kumar R, Kabdal T, Arya S, Dubey SK, Rawat DS, Kumar S (2025) First Report on Seasonal Variations in Chemical Composition and Pesticidal Activities of Alpinia nigra Rhizome Essential Oil, Biochemical systematics and ecology 123, 105055 https://doi.org/10.1016/j.bse.2025.105055 (IF- 2.2)
  8. Gairola K, Dubey SK. (2025) In-silico analysis of curcumin conjugates targeting the Wnt signaling pathway in Breast Cancer Stem Cells. Pantnagar journal of research 23(1): 1-7
  9. Pujari R, Saxena M, Dubey SK. (2025) Molecular docking analysis of curcumin curcumin-glucose conjugates as potential modulators of BCSC stemness via beta catenin inhibition. Pantnagar journal of research 23(3): 93-99
  10. Bahuguna A, Arti, Dubey SK* (2024) Phytochemical Profiling, Molecular Docking, and ADMET Evaluation of Essential Oils from Anaphalis busua and Anaphalis margaritacea in uttarakhand’s Himalayan Terrain. Phytomedicine plus 4:100645 https://doi.org/10.1016/j.phyplu.2024.100645
  11. Rawat S, Rai S, Sangeeta S, Kumar A, Ramchandran P, Sharka Sk, Dubey Sk, Pakash A, Joshi R (2024) Application of Plant-Based Hydrocolloids on the Textural Profile of Vegan Gummies Supplemented with Turmeric and Black Pepper. International Journal of food science https://doi.org/10.1155/2024/7127635 (IF- 3.9)
  12. Bargali P B, Kumar R, Devrani A, Mahawer S, Karkoti H, Prakash O, Kumar S, Rawat S, Rawat DS, Dubey SK, Seth CS, Ahmad F (2024) Essential oils work synergistically to mitigate pathogenic impact of Meloidogyne incognita, Rhizoctonia solani and Sclerotinia rolfsii. Biocatalysis and Agricultural Biotechnology 58(2024) 103160 (IF: 4.0) https://doi.org/10.1016/j.bcab.2024.103160
  13. Verma B, Arya S, Kabdal T, Arya V, Prakash O, Kumar R, Dubey SK Rawat DS, Tripathi S (2024) Phytochemical Analysis and Therapeutic Applications of Some Wild Edible Fruits Growing in Uttarakhand Himalayas". European Journal of Chemistry 15(2): 110-119 DOI: 10.5155/eurjchem.15.2.110-119.2520
  14. Rathore AS, Bhatt P, Vatsya S, Singh JL, Kumar R, Dubey SK (2023). Effect of fenbendazole and ivermectin on antioxidant status of goats suffering from gastrointestinal nematodes. The Pharma innovational journal SP-12(8): 31-35
  15. Arti, Bahuguna A, Arya A, Dubey SK*, Singh K*, Kumar R, Prakash O, Rawat DS, Arya P (2023). Validation of biological activities and characterization of extracts of Anaphalis margaritacea (L.) BENTH. & HOOK.F. from hilly terrains of Uttarakhand Himalaya. The Bioscan 18(2):75-80.
  16. Gururani S, Gairola K, Dubey SK*. Singh K*, Kumar R, Prakash O, Arya P (2023). Comparative evaluation of phytochemical composition, antioxidant, anti-inflammatory, and antidiabetic activities of curcuma amada and curcuma longa essential oil from Uttarakhand, India, The Bioscan 18(1):7-12.
  17. Bahuguna A, Dubey SK* (2023) Overview of mechanistic potential of probiotics and prebiotics in cancer chemoprevention. Molecular Nutrition and Food Research 67(19): e2300221 http://doi.wiley.com/10.1002/mnfr.202300221 (IF-5.2)
  18. Bahuguna A, Dubey SK* (2023) Relevance of Tumor Microbiome in Cancer Incidence, Prognosis, and its Clinical Implications in Therapeutics. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1878(5), 188956 https://doi.org/10.1016/j.bbcan.2023.188956 (IF-11.2)
  19. Arya A, Dubey SK*, Lauthani A, Bahuguna A, Kumar R, Prakash O, Rawat DS. (2023) Phytochemical profile and antioxidant potential of extracts of Callicarpa macrophylla Vahl. from Uttarakhand Himalayan region. International Journal of Plant Based Pharmaceuticals, 3(2), 131-140 https://doi.org/10.29228/ijpbp.25
  20. Garia V, Dubey SK*, Bahuguna A, Kumar R, Prakash O, Rawat DS. (2023) Composition, antioxidant, and anti-inflammatory activities of different polarity extracts of Artemisia nilagirica collected from hilly areas from the Himalayan terrain of Uttarakhand. European journal of Chemistry 14(3), 323-329 https://dx.doi.org/10.5155/eurjchem.14.3.323-329.2449
  21. Mahawer S, Kumar R, Prakash O, Rawat DS, Dubey SK, Olivera M. (2023). A review of phytochemical and pharmacological properties of Alpina malaccenis (Burm. F.) Roscoe. (Zingiberaceae) Current topics in Medicinal Chemistry 23(20), 1964-1972 DOI: 10.2174/1568026623666230522104104 (IF- 3.4)
  22. Pujari R, Dubey SK*. (2024) Relevance of glyco-biomakers and glycan profiles in cancer stem cells. Glycobiology, 34(6) cwad019. https://doi.org/10.1093/glycob/cwad019 (IF- 4.3)
  23. Bahuguna A, Dubey SK*, Garia V, Kumar R, Prakash O, Rawat DS. (2023) Composition, antioxidant, and anti-inflammatory activities of different polarity extracts of Anaphalis busua from the Himalayan terrain of Uttarakhand. European journal of Chemistry, 14(1), 114-120. https://dx.doi.org/10.5155/eurjchem.14.1.114-120.2395 (IF- 0.6)
  24. Sethi S, Prakash O, Kumar R, Dubey SK, Arya M, Pant A. (2022) Phytochemical Analysis, Antioxidant and Antifungal Activity of Essential oil and Extracts of Alpiniamalaccensis (Burm.f.) Roscoe flowers. Brazilian Journal of Pharmaceutical Sciences 58, e201209 DOI: 10.1590/s2175-97902022e201209 (IF- 1.6)
  25. Gairola K, Gururani S, Kumar R, Prakash O, Agarwal S, Dubey SK*. (2022) Composition, Antioxidant and Anti-inflammatory activities of Hexane and Methanol extracts of Acmella uliginosa form Terai region of Uttarakhand. Brazilian Journal of Pharmaceutical Sciences 58, e20353 DOI: 10.1590/s2175-97902022e20353 (IF- 1.6)
  26. Kabdal T, Himani, Kumar R, Prakash O, Nagarkoti K, Rawat DS, Srivastava RM, Kumar S, Dubey SK (2022) Seasonal variation in the essential oil composition and biological activities of Thymus linearis Benth. collected from Kumaun region of Uttarakhand, India. Biochemical Systematics and Ecology 103 (2022) 104449. https://doi.org/10.1016/j.bse.2022.104449 (IF- 1.6)
  27. Gururani S, Gairola K, Kumar R, Prakash O, Agarwal S, Dubey SK*. (2022) Altitudinal variations in phytochemical composition and biological activities of Curcuma longa accession from Uttarakhand, Himalayan region. Journal of food processing and preservation 46(3) e16384. DOI: 10.1111/jfpp.16384 (IF- 2.5)
  28. Gairola K, Gururani S, Bahuguna A, Garia V, Pujari R, Dubey SK*. (2021) Natural products targeting cancer stem cells: Implications for cancer chemoprevention and therapeutics. Journal of Food Biochemistry. 24(7)e13772 https://doi.org/10.1111/jfbc.13772 (IF- 4.00)
  29. Gairola K, Gururani S, Kumar R, Prakash O, Agarwal S, Dubey SK*. (2021) Composition, Antioxidant and Anti-inflammatory activities of essential oil of Acmellauliginosa from Terai region of Uttarakhand. Trends in Phytochemical research. 5 (1), 44-52. https://doi.org/10.30495/tpr.2021.680495
  30. Mishra H, Kesharwani RK*, Singh DV, Tripathi S, Dubey SK*, Misra K. (2019) Computational simulation of inhibitory effects of curcumin, retinoic acid, and their conjugates for GSK-3 beta. Network Modeling Analysis in Health Informatics and Bioinformatics. 8: 3. https://doi.org/10.1007/s13721-018-0177-x (IF-1.20)
  31. Srivastava RM, Singh S, Dubey SK, Misra K, Khar A. (2011). Immunomodulatory and therapeutic activities of curcumin. International Immunopharmacology, 119(3), 331-341. DOI: 10.1016/j.intimp.2010.08.014 (IF-5.6)
  32. Kakarala M, Dubey SK, Dobry C, Xijian P, Murillo G, Parikh S, Amarasinghe C, Mehta R, Brenner DE. (2011). Vitamin D compounds induce BRCA1 expression and inhibit breast stem cells. Cancer Research, 71(8 supplement) – 1842. https://doi.org/10.1158/1538-7445.AM2011-1842 (IF-11.2)
  33. Krishna S#, Ray A#, Dubey SK#, Larrouy-Maumus G, Chalut C, Castanier R, Noguera A, Gilleron M, Puzo G, Vercellone A, Nampoothiri KM, Nigou J. (2011) Lipoglycans contribute to innate immune detection of mycobacteria. PLoS One, 6(12):e28476. (#equal contribution) DOI: 10.1371/journal.pone.0028476 (IF-3.75)
  34. Mythri RB, Harish G, Dubey SK, Misra K, Bharath MMS. (2011) Glutamoyldiester of the dietary polyphenol curcumin offers improved protection against peroxynitrite mediated nitrosative stress and damage of brain mitochondria in vitro: Implications for Parkinson’s disease. Molecular and Cellular Biochemistry, 347(1-2):135-43. DOI: 10.1007/s11010-010-0621-4 (IF-3.84)
  35. Kakarala M, Dubey SK, Tarnowski M, Cheng C, Liyanage S, Tazi K, Sen A, Djuric Z, Brenner DE. (2010) Ultralow flow liquid chromatography assay with UV detection for piperine quantitation in human plasma. Journal of Agricultural Food Chemistry, 58 (11), 6594-6599. DOI: 10.1021/jf100657r (IF-6.1)
  36. Harish G, Mythri RB, Venkateshappa C, Dubey SK, Misra K, Singh N, Vali S, Bharath MMS. (2010). Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson disease. Bioorganic and. Medicinal Chemistry 18, 2631-2638. (IF-3.5) DOI: 10.1016/j.bmc.2010.02.029
  37. Dubey SK, Sharma AK, Narayan U, Misra K, Pati U. (2008) Design, synthesis, and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenatedpiperic acid and study of their antimicrobial and antiproliferative properties. European journal of medicinal chemistry. 43, 1837-1846. DOI: 10.1016/j.ejmech.2007.11.027 (IF-6.7)
  38. Dubey SK, Dwivedi V, Misra K. (2007) Novel method for synthesis of monoesters of symmetric diphenolic compounds like curcumin (1, 7-Bis (4-hydroxy-3-methoxy phenyl) 1, 6-hepta diene-3, 5-dione) via solid phase synthesis. Synthetic communication, 37, 4265-4271. https://doi.org/10.1080/00397910701575863 (IF-2.1)
  39. Dubey SK, Pandey A, Mishra R, Kapoor N, Misra K. (2007) Site specific drug delivery by non-viral mode. Indian journal of biotechnology, 6, 159-174. (IF-0.324)
  40. Dubey SK, Pandey A, Bajaj AK, Misra K. (2007) Some commercial azo dyes as Inhibitors of mushroom tyrosinase DOPA oxidase activity. Journal of Pharmacology and toxicology, 2(8), 718-724. DOI: 10.3923/jpt.2007.718.724
  41. Dubey SK, Misra K, Tiwari A, Bajaj AK. (2006). Chemically induced pigmentary changes of human skin: interaction of some azo dyes with human DNA. Journal of pharmacology and toxicology, 1(3), 234-247. DOI: 10.3923/jpt.2006.234.247
  42. Dubey SK, Sharma A, Kumar A, Pati U, Tiwari A, Misra K. (2006) Design and synthesis of a modified RNA- curcumin-demethylenatedpiperoyl conjugate as a telomerase targeted antisense prodrug, its activity against human cancer cell lines Hela & KB. Medicinal Chemistry Research, 15(1-6), 164-165. https://doi.org/10.1007/s00044-006-1503-x (IF-2.351)
  43. Bajaj AK, Dubey SK, Misra K. (2004) A simple spectroscopic technique proposed for scanning the depigmenting potential for azo dyes. Contact Dermatitis, 51(2), 97-98. DOI: 10.1111/j.0105-1873.2004.0396j.x (IF-5.5)

Books / Book Chapters

Book Edited/Adapted

  • Mehtab S, Zaidi M.G.H., Dubey SK (Eds). (2026) “Biomass Composites for Energy Storage” Springer Nature press (Accepted)
  • Mehtab S, Zaidi M.G.H., Dubey SK (Eds). (2026) “Nanomaterials for Sustainable Bioenergy Production, CRC Press ISBN 9781041094869 https://doi.org/10.1201/9781003650683
  • Dubey SK (Ed). (2023) Natural Products and nano-formulations in Cancer Chemoprevention. CRC Press, ISBN 9781032313030 https://doi.org/10.1201/b23311
  • Contributed additional content and questions with answers for the development of 4 book chapters in an Indian adaption of the book “Textbook of Biochemistry with Clinical Correlations”, 7th Edition by Thomas M. Devlin (Editor) Published by Wiley India (2022) (ISBN 9789354641558)
  • Contributed additional content and questions with answers for the development of 3 book chapters in an International adaption of the book “Essential Biochemistry, 7th Edition by Charlotte W. Pratt (Editor) Published by Wiley India (2024)

Book Chapters

  1. Gururani S, Gairola K, Dubey SK*. (2022), Antioxidant and immunomodulation In: Kesharwani, R.K., Keservani, R.K., Sharma, A.K. (eds) Immunomodulators and Human Health. Springer, Singapore. pp 101-121, https://doi.org/10.1007/978-981-16-6379-6_4 ISBN- 978-981-16-6378-9
  2. Gairola K, Gururani S, Dubey SK*. (2022), Polyphenols and its effect on immune system, In: Kesharwani, R.K., Keservani, R.K., Sharma, A.K. (eds) Nutraceuticals and Functional Foods in Immunomodulators. Springer, Singapore. pp. 121-140 DOI: https://doi.org/10.1007/978-981-19-2507-8_5 ISBN- 978-981-19-2506-1
  3. Gairola K, Dubey SK*, Bahuguna A, Shruti. (2023), Nutrigenomics in cancer chemoprevention. In Dubey SK (Ed.) Natural products and nano-formulations in cancer chemoprevention, CRC Press pp. 165-181
  4. Bahuguna A, Dubey SK*, Gairola K, Pujari R. (2023), Overview of natural products and Nano formulations in cancer chemoprevention. in Dubey SK (Ed.) Natural products and nano-formulations in cancer chemoprevention, CRC Press pp. 1-19
  5. Naudiyal N, Rana GS, Adhikari A, Dubey SK. (2023), Fat Soluble Vitamins in Cancer Chemoprevention. in Dubey SK (Ed.) Natural products and nano-formulations in cancer chemoprevention, CRC Press pp. 39-55
  6. Bughani A, Maheshwari J, Dubey SK, Zaidi M.G.H., Mehtab S, (2026) Nanomaterials-Based Bioenergy Generation: An Updates and Challenges. In Mehtab S, Zaidi M.G.H., Dubey SK (Eds) Nanomaterials for Sustainable Bioenergy Production. CRC Press pp. 1-34. DOI: 10.1201/9781003650683-1

UG/PG/Ph.D. Student Information

  • Supervised 9 PG Thesis
  • Supervised 01 Ph.D. student
  • Supervised 2 UG Dissertation

Patents

Patents Filed

  • Application No: 202511010301 dated 07/02/2025 — Oral Vaccine against Salmonella typhimurium for Poultry salmonellosis

Additional Responsibilities

  • Nodal Scientist, Intellectual property management cell (IPMC cell) in IDP-NAHEP, G.B. Pant University of Agriculture and Technology, Pantnagar (Aug 2020-October 2021)
  • Co-staff counselor for Basic Sciences and Humanities Society (2022-23)
  • Joint-faculty Secretary for the Board of Faculty of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar (2022-24)
  • Joint Coordinator, B. Tech (Biotech) program, C.B.S.H., G.B. Pant University of Agriculture and Technology, Pantnagar (Nov 2022-Till date)
  • Staff counselor Post Graduate (PG) Society, G.B. Pant University of Agriculture and Technology, Pantnagar (2022-23)
  • Staff counselor for Basic Sciences and Humanities Society (Jan 24- Aug 2025)
  • Faculty Secretary for the Board of Faculty of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar (July 2024-till date)

Professional Achievements & Awards

Honors/Awards

  • 2002 — Qualified NET-LS (National Eligibility Test for lectureship) and JRF (Junior Research Fellowship) conducted by UGC-CSIR, India
  • 1999 — Bronze Medal in B.Sc. Biology Group, Ewing Christian College, University of Allahabad, India.
  • 2022 — Best researcher award in the International Research Awards on Science, Technology and Management - INSO, Organized by VDGOOD Professional Association, India.

Post-Doctoral Experience

  • May 2009 - Dec 2011: Postdoc Fellow, University of Michigan, Ann Arbor, MI, USA
  • Apr 2007 - Mar 2009: Postdoc Fellow, Institute of Pharmacology and Structural Biology, CNRS, Toulouse, France

Membership of Professional Bodies

  • Life member of “Society of Biological Chemists”, India.
  • Life member of “National Academy of Biological Sciences”, India.

Links

Lab webpage:   https://stemcellresearch774.wixsite.com/stemcell

Google Scholar:   https://scholar.google.com/citations?user=ESxezC0AAAAJ&hl=en

ResearchGate:   ResearchGate

ORCID:   ORCID

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